Andersen Lab for Biomolecular Design

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 BION
Lab BBQ August 2023 in front of iNANO.
Cryo-EM reveals structure, folding and flexibility of cotranscriptional RNA origami (McRae et al., Nature Nanotechnology 2023).
RNA origami design software enables production of high-quality scaffolds for organizing proteins (Geary et al., Nature Chemistry 2021).
We developed a multi-fluorophore biosensor for easy detection in fluorescence microscopes (Selnihhin et al., ACS Nano 2018).
We developed aptamer-based FRET and implemented RNA origami devices (Jepsen et al., Nature Comm. 2018).
We developed an RNA origami octahedron with 6 intrinsic siRNAs for potent knockdown (Høiberg et al., Biotechnology Journal 2018).
We designed a DNA nanovault to encapsulate and control enzymes (Grossi et al., Nature Comm. 2017).
We visualized the molecular landscape of Streptococcus pneumoniae (Engholm et al., FEMS Microbiology Reviews 2017).
We invented the single stranded RNA origami method (Geary, Rothemund & Andersen, Science 2014).
We designed DNA origami boxes with controllable lids (Andersen et al., Nature 2009).

Welcome to the Andersen Lab for Biomolecular Design

We design nano-scale devices using biomolecules as building blocks. Our research aims at understanding the fundamental principles of how biomolecules fold into unique and functional shapes and at using this insight to guide the design of novel nanoscale devices for both basic science and technological applications. This website provides an overview of our research group and our research and teaching activities.

Latest News

Upcoming Events

CryoNET meeting in Stockholm

4 Oct
2 days, Wednesday 4 October 2023, at 10:00 - 5 October

Emil and Nikolaj will attend the CryoNET meeting in Stockholm. Emil will be giving a talk on cryo-EM of RNA polymerase ribozymes and their substrates.

Lecture by Sonia Contera and workshop

6 Oct
15 days, Friday 6 October 2023, at 10:15 - 22 September

As a start of the PhD school we will have an outreach lecture by Professor Sonia Contera from Oxford University followed by a "design thinking" workshop arranged by Julian and Ebbe.

Autumn school

7 Oct
3 days, Saturday 7 October 2023, at 10:00 - 9 October

Nikolaj and Martin will attend the iNANO autumn school at Fuglsø.

Danish RNA Society meeting

10 Oct
Tuesday 10 October 2023, at 09:00

Ebbe will be giving a short talk on cryo-EM of RNA structures.

DNA and RNA Origami Symposium

14 Nov
Tuesday 14 November 2023, at 07:00

DNA and RNA Origami Symposium in Perth, Australia.

Synthetic Biology Australasia in Perth

15 Nov
3 days, Wednesday 15 November 2023, at 12:00 - 17 November

Ebbe will be attending SBA in Perth, where he will be giving a key-note talk.

iNANO lecture by Phil Holliger

24 Nov
52 days, Friday 24 November 2023, at 10:15 -

About

The Andersen Lab is located at the Interdisciplinary Nanoscience Center, Aarhus University, Aarhus, Denmark. We are also affiliated with the Department of Molecular Biology and Genetics. If you are interested in working with us please contact Ebbe S. Andersen by phone or email.

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Funding

The lab is currently funded by:

  • An Interdisciplinary Synergy grant from the Novo Nordisk Foundation for the project "COFOLD - Co-transcriptional folding for RNA medicine and synthetic biology"
  • An Ascending Investigator Grant from the Novo Nordisk Foundation for the project "RNA-based platform for metabolic pathway engineering"
  • A grant from the Novo Nordisk Foundation for the project "Genetically encoded RNA-based FRET biosensors for improving production strains of valuable small molecules and recombinant proteins"
  • A Research Project 1 grant from the Independent Research Fund Denmark for the project "Cryo-EM analysis of RNA-protein complexes using RNA origami scaffolds"
  • An equipment grant from the Carlsberg Foundation for the project "Optimization of Cryo-EM characterization pipeline for biomolecular nanostructures"
  • A grant from the Innovation Fund Denmark for the PhD project "Developing fluorescent aptamer sensors for high-throughput screening of secretory phenotypes in droplets"
  • A grant from the European Commission – Marie Skłodowska-Curie Actions supporting the DNA Robotics PhD school and the PhD project "RNA-based modules DNA nanorobots"

The lab was previously funded by:

  • A Consolidator Grant from the European Research Council for the project "RNA ORIGAMI: RNA-protein Nanostructures for Synthetic Biology"
Revised 04.10.2023
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Ebbe Sloth Andersen