Andersen Lab for Biomolecular Design

Aarhus University Seal / Aarhus Universitets segl

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Group picture in front of iNANO July 2020.
We invented the single stranded RNA origami method (Geary, Rothemund & Andersen, Science 2014).
We developed a multi-fluorophore biosensor for easy detection in fluorescence microscopes (Selnihhin et al., ACS Nano 2018).
We designed a DNA nanovault to encapsulate and control enzymes (Grossi et al., Nature Comm. 2017).
We developed aptamer-based FRET and implemented RNA origami devices (Jepsen et al., Nature Comm. 2018).
We developed an RNA origami octahedron with 6 intrinsic siRNAs for potent knockdown (Høiberg et al., Biotechnology Journal 2018).
We visualized the molecular landscape of Streptococcus pneumoniae (Engholm et al., FEMS Microbiology Reviews 2017).
We designed DNA origami boxes with controllable lids (Andersen et al., Nature 2009).

Welcome to the Andersen Lab for Biomolecular Design

We design nano-scale devices using biomolecules as building blocks. Our research aims at understanding the fundamental principles of how biomolecules fold into unique and functional shapes and at using this insight to guide the design of novel nanoscale devices for both basic science and technological applications. This website provides an overview of our research group and our research and teaching activities.

Latest news

2021.01.02 | Publication

Research paper: Flexibility of RNA junctions

We have published a paper with our collaborators on the application of apta-FRET for studying the flexibility of RNA junctions.

2020.12.03 | Awards

Funding: Carlsberg equipment grant

The lab has received funding from the Carlsberg Foundation for new purification equipment and computer ressources for cryo-EM research.

2020.12.01 | People

Cody gets 3-year assistant professor position

Cody gets 3-year position as assistant professor in RNA nanotechnology funded by our recent Novo Nordisk Foundation grant and the CELLPAT center of Professor Jørgen Kjems.

2020.11.20 | Awards

Funding: Network with Japanese researchers

Grant from the Ministry of Education and Research to establish research collaborations with researchers from Japan. Project is led by Associate Professor Frans Mulder and also involves Daniel Otzen and our research group.

2020.11.01 | People

Adrien gets 2-year Postdoc position

Adrien got a 2-year postdoc position in the lab to further develop in vitro selection methods for sensor application funded by the Novo Nordisk Foundation.

Upcoming events

Thu 22 Apr
16:00-18:00 | Zoom
PhD defence: Michael Nguyen
Michael will defend his PhD thesis on "Engineering RNA-Protein Nanoscaffolds for Synthetic Biology". Opponents are Associate Professor Elisa Franco, UCLA, and Associate Professor Jeppe Vinther, University of Copenhagen. Chairman from Graduate School of Natural Sciences (GSNS) is Professor Jørgen Kjems.

About

The Andersen Lab is located at the Interdisciplinary Nanoscience Center, Aarhus University, Aarhus, Denmark. We are also affiliated with the Department of Molecular Biology and Genetics. If you are interested in working with us please contact Ebbe S. Andersen by phone or email.

Funding

The lab is currently funded by:

  • A Consolidator Grant from the European Research Council for the project "RNA ORIGAMI: RNA-protein Nanostructures for Synthetic Biology"
  • An Ascending Investigator Grant from the Novo Nordisk Foundation for the project "RNA-based platform for metabolic pathway engineering"
  • A grant from the Novo Nordisk Foundation for the project "Genetically encoded RNA-based FRET biosensors for improving production strains of valuable small molecules and recombinant proteins"
  • A Research Project 1 grant from the Independent Research Fund Denmark for the project "Cryo-EM analysis of RNA-protein complexes using RNA origami scaffolds"
  • An equipment grant from the Carlsberg Foundation for the project "Optimization of Cryo-EM characterization pipeline for biomolecular nanostructures"
  • A grant from the Innovation Fund Denmark for the PhD project "Developing fluorescent aptamer sensors for high-throughput screening of secretory phenotypes in droplets"
  • A grant from the European Commission – Marie Skłodowska-Curie Actions supporting the DNA Robotics PhD school and the PhD project "RNA-based modules DNA nanorobots"

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Revised 22.01.2021 - 
Ebbe Sloth Andersen