Andersen Lab for Biomolecular Design

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 BION
Lab BBQ June 2024 in front of iNANO.
Cryo-EM structure of an RNA polymerase ribozyme (McRae et al., PNAS 2024).
Cryo-EM reveals structure, folding and flexibility of cotranscriptional RNA origami (McRae et al., Nature Nanotechnology 2023).
RNA origami design software enables production of high-quality scaffolds for organizing proteins (Geary et al., Nature Chemistry 2021).
We developed a multi-fluorophore biosensor for easy detection in fluorescence microscopes (Selnihhin et al., ACS Nano 2018).
We developed aptamer-based FRET and implemented RNA origami devices (Jepsen et al., Nature Comm. 2018).
We developed an RNA origami octahedron with 6 intrinsic siRNAs for potent knockdown (Høiberg et al., Biotechnology Journal 2018).
We designed a DNA nanovault to encapsulate and control enzymes (Grossi et al., Nature Comm. 2017).
We visualized the molecular landscape of Streptococcus pneumoniae (Engholm et al., FEMS Microbiology Reviews 2017).
We invented the single stranded RNA origami method (Geary, Rothemund & Andersen, Science 2014).
We designed DNA origami boxes with controllable lids (Andersen et al., Nature 2009).

Welcome to the Andersen Lab for Biomolecular Design

We design nano-scale devices using biomolecules as building blocks. Our research aims at understanding the fundamental principles of how biomolecules fold into unique and functional shapes and at using this insight to guide the design of novel nanoscale devices for both basic science and technological applications. This website provides an overview of our research group and our research and teaching activities.

About

The Andersen Lab is located at the Interdisciplinary Nanoscience Center, Aarhus University, Aarhus, Denmark. We are also affiliated with the Department of Molecular Biology and Genetics. If you are interested in working with us please contact Ebbe S. Andersen by phone or email.

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Funding

The lab is currently funded by:

  • An Interdisciplinary Synergy grant from the Novo Nordisk Foundation for the project "COFOLD - Co-transcriptional folding for RNA medicine and synthetic biology"
  • An Ascending Investigator Grant from the Novo Nordisk Foundation for the project "RNA-based platform for metabolic pathway engineering"
  • A grant from the Novo Nordisk Foundation for the project "Genetically encoded RNA-based FRET biosensors for improving production strains of valuable small molecules and recombinant proteins"
  • A Research Project 1 grant from the Independent Research Fund Denmark for the project "Cryo-EM analysis of RNA-protein complexes using RNA origami scaffolds"
  • An equipment grant from the Carlsberg Foundation for the project "Optimization of Cryo-EM characterization pipeline for biomolecular nanostructures"
  • A grant from the Innovation Fund Denmark for the PhD project "Developing fluorescent aptamer sensors for high-throughput screening of secretory phenotypes in droplets"
  • A grant from the European Commission – Marie Skłodowska-Curie Actions supporting the DNA Robotics PhD school and the PhD project "RNA-based modules DNA nanorobots"

The lab was previously funded by:

  • A Consolidator Grant from the European Research Council for the project "RNA ORIGAMI: RNA-protein Nanostructures for Synthetic Biology"
Revised 23.01.2025
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Ebbe Sloth Andersen